Job Specifications
About Us
The hosting structure
Institut Curie Research Center
Institut Curie is a major player in the research and fight against cancer. It consists of a Hospital group and a Research Center of more than 1000 employees with a strong international representativeness.
The objective of the Research Center is to develop basic research and to use the knowledge produced to improve the diagnosis, prognosis, and therapeutics of cancers as part of the continuum between basic research and innovation serving the patient.
Mission
Context
Laboratory
The successful candidate (F/M) will join Valerie Borde's team belonging to the Institut Curie Research Center and affiliated to the Dynamics of Genetic Information department.
The Institut Curie is a highly vibrant research center, offering an international and multidisciplinary research environment in central Paris.
The Chromosome Dynamics and Recombination team led by Valerie Borde, studies the mechanisms involved in the repair of double-strand breaks during meiosis and somatic growth, combining cutting-edge genomics, proteomics and molecular biology technologies (https://institut-curie.org/team/borde). It is a highly dynamic international group currently including 2 PhD students, 1 post-doc, 4 engineers and 2 staff scientists. In addition to in-house scientific and technical skills provided by team members, the post-doctoral fellow will benefit from the stimulating and collaborative environment of the Institut Curie Research Center and from its cutting-edge technological platforms.
Recent Publications
Nicolas, Y., Bret, H., Cannavo, E., Acharya, A., Cejka, P.#, Borde, V.# and Guerois, R.# (2024) "Molecular insights into the activation of Mre11-Rad50 endonuclease activity by Sae2/CtIP." Molecular Cell 84, 2223-2237.
Pyatnitskaya, A., Andreani, J., Guerois, R., De Muyt, A. and Borde, V. (2022) The Zip4 protein directly couples meiotic crossover formation to synaptonemal complex assembly. Genes and Development 36, 53-69.
Cohen, S., Guenole, A., Lazar, I., Marnef, A., Clouaire, T., Vernekar, D., Puget, N., Rocher, V., Arnould, C., Aguirrebengoa, M., Genais, M., Firmin, N., Shamanna, R., Mourad, R., Bohr, W., Borde, V. and Legube, G. (2022) A POLD3/BLM dependent pathway handles DSBs in transcribed chromatin upon excessive RNA:DNA hybrids accumulation. Nature Communications 13, 2012.
The project
This exciting project will focus on the study of the molecular mechanisms of DSB repair in normal and recombination-deficient human cells at defined genomic locations to explore different genomic contexts. The post-doc will use innovative unpublished genomic approaches in combination with genetic, molecular and genome editing approaches. The project will be made with the support from Institut Curie genomic facilities, and from an engineer in the lab for computational analyses.
Profile
Candidate Profile
Training And Skills Required
Training: We invite applications from candidates with a strong interest in DNA repair and chromosome biology, and a strong experience in manipulating human cell lines. Ideally (but not mandatory) with a mixed background in molecular biology and computational analyses of genomic data.
Scientific skills: Candidates holding, or shortly expecting to be awarded, a PhD degree in related fields are encouraged to apply.
Applicants should have at least one publication as first author.
Language skills: Candidates should be fluent in English, which is the language used in the lab.
Abilities
Highly self-motivated
Rigorous
Creativity, ability to work independently and to collaborate with others
All Our Opportunities Are Open To People With Disabilities
Contract information
Type of contract: Fixed-term contract.
Starting date: from October 15th 2025
Duration: initial, renewable 12 months funding will be provided, and the candidate should also be competitive to apply for postdoctoral fellowships.
Working time: full time
Remuneration: according to Institut Curie current grids
Benefits: Collective catering, reimbursement of transportation fees up to 70%, supplementary health insurance
Location of the position: Paris
Contact
Please send your CV, letter of motivation and the name of 2 references
Publication date: 10/09/2025
Deadline for application: until filled
Institut Curie is an inclusive, equal opportunity employer
and is dedicated to the highest standards of research integrity.
https://euraxess.ec.europa.eu/sites/default/files/brochures/eur_21620_en-fr.pdf
Reference de l'offre : rw38kq3jqm