- Company Name
- The Hospital for Sick Children
- Job Title
- Scientist, Genetics & Genome Biology
- Job Description
-
Job title: Scientist, Genetics & Genome Biology
Role Summary: Independent faculty researcher within a pediatric research institute, focused on human genetics, gene editing, functional genomics, systems biology, and therapeutic development for child health. Leads original research program, secures funding, publishes in top journals, teaches, and supervises trainees.
Expectations:
- Initiate and sustain an internationally competitive, independently funded research program in human genetics and disease modeling.
- Secure external research funding (fellowships, NIH/CIHR grants, industry partnerships) and maintain a high publication record in peer‑reviewed, high‑impact journals.
- Build capacity in advanced genomics, proteomics, single‑cell analysis, high‑resolution microscopy, computational modeling, and AI-driven discovery.
- Deliver lectures, seminars, and mentorship to graduate students, postdoctoral fellows, and junior investigators; achieve academic cross‑appointment in an appropriate U. of Toronto department.
- Foster collaborative projects within the Research Institute’s multidisciplinary core facilities and across the broader university community.
Key Responsibilities:
- Design and execute research projects exploring gene/variant function, epigenetic regulation, and disease mechanisms using cellular, animal, and organoid models.
- Apply genome editing (CRISPR/Cas9, base editors, prime editors) to create disease models and test therapeutic strategies.
- Perform multi‑omics profiling (genomics, transcriptomics, proteomics, metabolomics) and integrate data via computational biology and AI approaches.
- Conduct high‑throughput compound screening, structure‑based drug discovery, and protein engineering to identify and validate therapeutic targets.
- Draft and submit grant proposals, manage budgets, and report progress to funding agencies and institutional review boards.
- Publish results, present at national and international conferences, and contribute to the institute’s translational impact on child health.
Required Skills:
- Deep expertise in human genetics, functional genomics, and gene editing technologies.
- Proficiency in systems biology, bioinformatics, protein engineering, and AI/machine‑learning for biological data analysis.
- Experience with high‑throughput screening, advanced microscopy, and multi‑omics platforms.
- Strong grant writing, project management, and academic leadership abilities.
- Effective communication skills for teaching, mentoring, and scientific dissemination.
Required Education & Certifications:
- PhD, MD, or MD/PhD in genetics, molecular biology, bioinformatics, or related discipline.
- Minimum 2–3 years postdoctoral research experience with a demonstrable record of publications, grant success, and peer recognition.
- Laboratory accreditation in gene‑editing, genomics, or proteomics techniques is preferred.